:root{
  --bg:#eef1f5;
  --panel:#ffffff;
  --ink:#1b2430;
  --ink-soft:#5b6b7c;
  --line:#d6dee7;
  --accent:#0b6cb1;
  --accent-soft:#e3f0fa;
  --port:#c2410c;
  --port-h:#94a3b8;
  --danger:#b91c1c;
  --board:#fbfcfd;
  --shadow:0 1px 2px rgba(16,32,48,.06),0 4px 12px rgba(16,32,48,.07);
}
*{box-sizing:border-box}
html,body{height:100%}
body{
  margin:0;background:var(--bg);color:var(--ink);
  font:14px/1.45 "Segoe UI",Roboto,Helvetica,Arial,sans-serif;
  overflow:hidden;
}
button{font:inherit;cursor:pointer}

/* ---------------- barre superieure ---------------- */
#topbar{
  height:52px;display:flex;align-items:center;gap:18px;padding:0 16px;
  background:var(--panel);border-bottom:1px solid var(--line);box-shadow:var(--shadow);
  position:relative;z-index:20;
}
.brand{display:flex;align-items:center;gap:9px;font-size:18px;font-weight:600;letter-spacing:-.2px}
/* la marque ne se coupe plus en deux : "Pasteur" est un seul mot */
.brand .sigle{width:28px;height:28px;flex:0 0 auto;display:block}
.langues{display:inline-flex; margin-left:12px; border:1px solid var(--line);
  border-radius:8px; overflow:hidden; background:#fff}
.langues button{border:0; background:transparent; color:var(--ink-soft);
  font:inherit; font-size:11px; letter-spacing:.08em; padding:4px 9px; cursor:pointer}
.langues button+button{border-left:1px solid var(--line)}
.langues button[aria-pressed="true"]{background:var(--accent); color:#fff}
.tools{display:flex;align-items:center;gap:8px}
.tool-label{color:var(--ink-soft);font-size:12px;text-transform:uppercase;letter-spacing:.06em}
.tools button{
  padding:6px 11px;border:1px solid var(--line);background:#fff;border-radius:6px;
  color:var(--ink);transition:background .12s,border-color .12s;
}
.tools button:hover{background:#f2f6fa;border-color:#bcc9d6}
.tools button:disabled{opacity:.4;cursor:default;background:#fff}
.tools button.danger{color:var(--danger);border-color:#f0d2d2}
.tools button.danger:hover{background:#fdf2f2}
.seg{display:flex;border:1px solid var(--line);border-radius:6px;overflow:hidden}
.seg button{border:0;border-radius:0;background:#fff;padding:6px 14px;font-size:16px;line-height:1}
.seg button+button{border-left:1px solid var(--line)}
.seg button.on{background:var(--accent);color:#fff}
.seg button.on:hover{background:var(--accent)}
.sep{width:1px;height:24px;background:var(--line)}
.hint{margin-left:auto;color:var(--ink-soft);font-size:13px;max-width:46ch;text-align:right}
.hint.warn{color:var(--danger)}

/* ---------------- disposition ---------------- */
#app{display:flex;height:calc(100% - 52px)}
aside{background:var(--panel);display:flex;flex-direction:column;min-height:0}
#palette{width:268px;border-right:1px solid var(--line)}
#result{width:340px;border-left:1px solid var(--line);padding:14px;gap:12px;overflow-y:auto}

/* ---------------- palette ---------------- */
.pal-search{padding:10px;border-bottom:1px solid var(--line)}
.pal-search input,.pal-custom input{
  width:100%;padding:7px 10px;border:1px solid var(--line);border-radius:6px;
  font:inherit;color:var(--ink);background:#fff;
}
.pal-search input:focus,.pal-custom input:focus{outline:2px solid var(--accent-soft);border-color:var(--accent)}
#pal-list{flex:1;overflow-y:auto;padding:4px 0 10px}
.cat>summary{
  padding:7px 12px;font-weight:600;font-size:12.5px;color:var(--ink-soft);
  text-transform:uppercase;letter-spacing:.05em;cursor:pointer;user-select:none;
  background:#f7f9fb;border-bottom:1px solid var(--line);position:sticky;top:0;z-index:2;
}
.cat>summary::marker{color:var(--accent)}
.grid{display:grid;grid-template-columns:1fr 1fr;gap:6px;padding:8px}
.frag{
  border:1px solid var(--line);border-radius:8px;background:#fff;padding:4px 2px 2px;
  display:flex;flex-direction:column;align-items:center;cursor:pointer;
  transition:border-color .12s,box-shadow .12s,transform .06s;
}
.frag:hover{border-color:var(--accent);box-shadow:0 2px 8px rgba(11,108,177,.15)}
.frag:active{transform:scale(.97)}
.frag svg{width:100%;height:58px;display:block}
.frag .nm{font-size:10.5px;color:var(--ink-soft);text-align:center;line-height:1.2;
  padding:2px 3px 3px;word-break:break-word}
.pal-custom{border-top:1px solid var(--line);padding:10px;display:flex;flex-direction:column;gap:7px}
.pal-custom label{font-size:12px;font-weight:600;color:var(--ink-soft);text-transform:uppercase;letter-spacing:.05em}
.pal-custom button{
  padding:7px;border:1px solid var(--accent);background:var(--accent);color:#fff;border-radius:6px;
}
.pal-custom button:hover{background:#095c97}
.pal-custom .note{margin:0;font-size:11px;color:var(--ink-soft);line-height:1.35}
.pal-custom code{background:#eef2f6;padding:0 3px;border-radius:3px;font-size:10.5px}

/* ---------------- plan de travail ---------------- */
#board{
  flex:1;position:relative;overflow:hidden;background:var(--board);
  background-image:radial-gradient(#d9e1ea 1px,transparent 1px);
  background-size:22px 22px;cursor:grab;
}
#board.panning{cursor:grabbing}
#world{position:absolute;top:0;left:0;transform-origin:0 0}
#wires{position:absolute;top:0;left:0;width:6000px;height:6000px;pointer-events:none;overflow:visible}
#wires line,#wires path{pointer-events:stroke}
#nodes{position:absolute;top:0;left:0}

.node{
  position:absolute;background:#fff;border:1px solid var(--line);border-radius:10px;
  box-shadow:var(--shadow);user-select:none;cursor:move;
}
.node.sel{border-color:var(--accent);box-shadow:0 0 0 2px var(--accent-soft),var(--shadow)}
.node .body{position:relative}
.node svg{display:block;pointer-events:none}
.node .cap{
  position:absolute;left:0;right:0;bottom:-17px;text-align:center;font-size:10.5px;
  color:var(--ink-soft);white-space:nowrap;overflow:hidden;text-overflow:ellipsis;
}
.node .del{
  position:absolute;top:-9px;right:-9px;width:19px;height:19px;border-radius:50%;
  border:1px solid var(--line);background:#fff;color:var(--danger);font-size:13px;line-height:1;
  display:none;align-items:center;justify-content:center;padding:0;
}
.node:hover .del{display:flex}
.node .del:hover{background:#fdf2f2;border-color:#f0d2d2}

.port{
  position:absolute;border-radius:50%;transform:translate(-50%,-50%);
  cursor:pointer;transition:transform .1s,background .1s;
}
.port.r{width:15px;height:15px;background:#fff;border:2.5px solid var(--port)}
.port.r:hover{transform:translate(-50%,-50%) scale(1.28);background:#ffe9df}
.port.h{width:9px;height:9px;background:#fff;border:2px solid var(--port-h);opacity:0}
.node:hover .port.h{opacity:.75}
.port.h:hover{opacity:1;transform:translate(-50%,-50%) scale(1.5);border-color:var(--accent)}
.port.used{background:var(--port);border-color:var(--port);cursor:default;opacity:.45}
.port.used:hover{transform:translate(-50%,-50%)}
.node .port.armed{
  background:var(--accent);border-color:var(--accent);opacity:1;
  box-shadow:0 0 0 5px rgba(11,108,177,.22);
}

#board-empty{
  position:absolute;inset:0;display:flex;flex-direction:column;align-items:center;
  justify-content:center;gap:6px;color:var(--ink-soft);pointer-events:none;text-align:center;
}
#board-empty p{margin:0;font-size:17px;font-weight:600}
#board-empty span{max-width:42ch;font-size:13px}
#zoom-badge{
  position:absolute;right:10px;bottom:10px;background:rgba(255,255,255,.92);
  border:1px solid var(--line);border-radius:6px;padding:3px 8px;font-size:11.5px;
  color:var(--ink-soft);pointer-events:none;
}

/* ---------------- panneau resultat ---------------- */
#result h2{margin:0;font-size:13px;text-transform:uppercase;letter-spacing:.06em;color:var(--ink-soft)}
#preview{
  border:1px solid var(--line);border-radius:10px;background:#fff;min-height:220px;
  display:flex;align-items:center;justify-content:center;overflow:hidden;
}
#preview svg{max-width:100%;height:auto}
#preview .ph{color:#c3ccd6;font-size:32px}
.smiles-block{display:flex;flex-direction:column;gap:5px}
.smiles-head{display:flex;align-items:center;justify-content:space-between}
.smiles-head span{font-size:12px;font-weight:600;color:var(--ink-soft);text-transform:uppercase;letter-spacing:.05em}
.smiles-head button{padding:4px 10px;border:1px solid var(--line);background:#fff;border-radius:6px}
.smiles-head button:hover{background:#f2f6fa}
#smiles{
  width:100%;resize:vertical;border:1px solid var(--line);border-radius:8px;padding:8px 9px;
  font:12.5px/1.45 "SFMono-Regular",Consolas,"Liberation Mono",monospace;
  color:var(--ink);background:#fbfcfd;
}
#msg{font-size:12.5px;color:var(--danger);min-height:1em}
#msg.info{color:var(--ink-soft)}
#props{width:100%;border-collapse:collapse;font-size:12.5px}
#props th{
  text-align:left;font-weight:500;color:var(--ink-soft);padding:5px 0;
  border-bottom:1px solid #eef2f6;width:52%;
}
#props td{text-align:right;padding:5px 0;border-bottom:1px solid #eef2f6;font-variant-numeric:tabular-nums}
.mono{font-family:"SFMono-Regular",Consolas,monospace}
.small{font-size:11px}
.exports{display:flex;gap:8px}
.exports button{
  flex:1;padding:7px;border:1px solid var(--line);background:#fff;border-radius:6px;
}
.exports button:hover{background:#f2f6fa}

@media (max-width:1180px){
  #palette{width:224px}
  #result{width:290px}
}

/* ---------------- retrosynthese ---------------- */
/* en tete du panneau : le trait de separation passe donc en dessous */
.retro-block{margin-bottom:18px; padding-bottom:16px; border-bottom:1px solid var(--line, #d8dbe0)}
.retro-block h2{margin:0 0 8px}
#btn-retro{width:100%; padding:10px; font-weight:600}
#btn-retro:disabled{opacity:.45; cursor:default}
#retro-etat{margin-top:10px; font-size:13px; min-height:18px}
/* tant qu'il n'y a rien a dire, le bloc ne reserve pas de place */
#retro-etat:empty{margin:0; min-height:0}
#retro-route:empty{margin:0}
#retro-etat .barre{height:5px; border-radius:3px; background:#e6e8ec; overflow:hidden; margin:8px 0}
#retro-etat .barre i{display:block; height:100%; width:0; background:#2f6f4f; transition:width .5s linear}
#retro-etat.bon{color:#2f6f4f; font-weight:600}
#retro-etat.mauvais{color:#a2483a}
#retro-route{margin-top:12px; font-size:12.5px}
#retro-route ul{list-style:none; margin:0; padding-left:14px; border-left:1px solid #dfe2e7}
#retro-route > ul{padding-left:0; border-left:0}
#retro-route li{margin:5px 0}
#retro-route .mol{font-family:ui-monospace,Menlo,Consolas,monospace; font-size:11.5px;
  word-break:break-all; line-height:1.45}
#retro-route .stock{color:#2f6f4f}
#retro-route .stock::before{content:"catalogue "; font-family:inherit; font-size:10.5px;
  letter-spacing:.04em; text-transform:uppercase; color:#7b8794; margin-right:4px}
#retro-route .fleche{color:#7b8794; margin:0 4px}
#retro-route .resume{margin:0 0 8px; color:#374151}
#retro-route .resume b{color:#111827}

/* ---------------- la route dans le plan de travail ---------------- */
#route-plan{position:absolute; inset:0; background:var(--bg, #fbfbfc); z-index:5;
  display:flex; flex-direction:column}
#route-plan[hidden]{display:none}
.rp-tete{display:flex; align-items:center; gap:14px; padding:10px 14px;
  border-bottom:1px solid #e3e6ea; background:#fff; flex:0 0 auto}
.rp-titre{font-weight:600; font-size:14px}
.rp-resume{font-size:13px; color:#6b7280; flex:1 1 auto}
#rp-fermer{font-size:13px; padding:6px 12px}
/* "safe center" centre tant que l'arbre tient dans la fenetre et colle a gauche des
   qu'il deborde. Avec un centrage ordinaire, la partie gauche d'un arbre trop large
   passe hors de la zone defilable et devient inatteignable. */
.rp-arbre{flex:1 1 auto; overflow:auto; padding:24px 20px 40px; display:flex;
  justify-content:safe center; align-items:flex-start}

/* un organigramme : chaque molecule au-dessus de ce qui la fabrique */
.rp-arbre ul{list-style:none; margin:0; padding:22px 0 0; display:flex;
  justify-content:center; align-items:flex-start; position:relative}
.rp-arbre > ul{padding-top:0}
.rp-arbre li{position:relative; padding:22px 10px 0; display:flex;
  flex-direction:column; align-items:center}
/* les traits de liaison, en bordures : pas de calcul de coordonnees */
.rp-arbre li::before, .rp-arbre li::after{content:""; position:absolute; top:0;
  width:50%; height:22px; border-top:1px solid #c8ccd2}
.rp-arbre li::before{right:50%; border-right:1px solid #c8ccd2}
.rp-arbre li::after{left:50%}
.rp-arbre li:only-child::before, .rp-arbre li:only-child::after{display:none}
.rp-arbre li:only-child{padding-top:22px}
.rp-arbre li:first-child::before, .rp-arbre li:last-child::after{border-top:0}
.rp-arbre li:last-child::before{border-right-color:#c8ccd2}
.rp-arbre > ul > li{padding-top:0}
.rp-arbre > ul > li::before, .rp-arbre > ul > li::after{display:none}
.rp-arbre ul ul::before{content:""; position:absolute; top:0; left:50%; height:22px;
  border-left:1px solid #c8ccd2}
.rp-mol{position:relative; background:#fff; border:1px solid #dfe3e8; border-radius:10px;
  padding:8px 8px 6px; width:168px; box-shadow:0 1px 2px rgba(20,24,30,.05)}
.rp-mol.rp-stock{border-color:#bcd8c6; background:#f6fbf7}
.rp-mol svg{width:100%; height:104px; display:block}
.rp-mol .rp-vide{height:104px; display:flex; align-items:center; justify-content:center;
  color:#9aa3ad; font-size:20px}
.rp-mol .rp-smiles{margin:4px 0 0; font-family:ui-monospace,Menlo,Consolas,monospace;
  font-size:10px; line-height:1.35; color:#5b636d; word-break:break-all; max-height:2.7em;
  overflow:hidden}
.rp-mol .rp-etiq{position:absolute; top:-9px; left:8px; font-size:9.5px; letter-spacing:.04em;
  text-transform:uppercase; background:#2f6f4f; color:#fff; padding:1px 6px; border-radius:6px}
.rp-mol .rp-sans{font-size:11px; color:#a2483a; text-align:center; line-height:1.3; padding:0 6px}